Palmitoylethanolamide (PEA) is a naturally occurring lipid compound gaining recognition in skincare for its ability to support the skin barrier, reduce visibly irritated skin, and promote long-term hydration. Previously studied in clinical and wellness settings, PEA is now being formulated into advanced skin serums that focus on resilience, balance, and comfort.
Let’s explore the science behind PEA, how it works, and why it may be the future of skin barrier repair and sensitive skin support.
PEA is a fatty acid amide naturally produced by the body. In dermatological applications, it has shown the potential to support skin health by reinforcing barrier integrity.
Specifically, PEA interacts with PPAR-α receptors in skin cells directly for cellular repair. This makes PEA a unique candidate for skincare aimed at calming irritated skin, hydration, and adding strength to the skin.
When used in topical formulations, PEA has been shown to:
These properties make PEA a strong candidate for anyone seeking a skin repair serum, especially one that supports sensitive or compromised skin types without the need for exfoliants or resurfacing agents.
A healthy skin barrier plays a critical role in keeping the skin hydrated, protected, and less reactive. Ageing, environmental stressors, over-exfoliation, and certain skin conditions can impair this barrier, leading to dryness, irritation and sensitivity.
PEA helps by:
As such, PEA is now appearing in hydrating face serums, barrier repair treatments and skincare targeted at reactive or redness-prone skin.
Genaura is proud to be the first skincare brand to incorporate Levagen®+, a highly bioavailable form of palmitoylethanolamide, into a topical serum.
Levagen®+ is engineered for enhanced absorption, allowing more effective delivery through the skin. In Genaura’s Smart Face Serum, it is combined with:
The result is a science-backed face serum that helps improve hydration, support skin barrier repair, and promote overall skin clarity and resilience.
Yes. PEA is considered a non-irritating, biocompatible active that works with the skin’s own systems. It does not exfoliate or force cell turnover, which makes it suitable for:
Patch testing is still recommended, but studies suggest that PEA is well-tolerated across a range of skin types.
A 2024 review published in the International Journal of Molecular Sciences (PMC10997259) highlights PEA’s role in enhancing hydration when used in topical skincare. Other studies show its ability to modulate immune responses within the skin and contribute to derma protection.
These effects reinforce PEA’s growing reputation as a dermaceutical ingredient, one that bridges the gap between traditional skincare and clinical-grade formulations.
Experience the next generation of skin support with our Smart Face Serum, formulated with Levagen®+, vitamins, and botanicals. A hydrating skin serum that works with your body, backed by science, designed for results.
